Is it safe to leave KeePass open?

Leaving KeePass open can pose potential security risks. While KeePass is designed to securely store passwords, leaving it open could expose sensitive information to unauthorized access. If an attacker gains access to the computer while KeePass is open, they could potentially view or steal passwords. It is recommended to close KeePass when not in use and to use additional security measures such as locking the computer or using a password manager with auto-lock features.

It is safe if your computer is safe from unauthorized access. This includes malware. If your computer is not physically safe, then no, anyone can access your Keepass. If your computer has malware on it, it can also access your Keepass if it is left unencrypted.